I am sure you had come across those patients who had been on aspirin & warfarin ..or...plavix & warfarin...or rarely all three (either intentionally or by mistake!!). Well...a patient with CAD might benefit more from a antiplatelet...but may need warfarin for A.fib ....will he benefit from both? A recent article from Arch of Int Medicine tried to address these issues by calculating the risk of bleeding associated with each combination.
Lets look at the risk of stoke with A fib at 1 year...so the numbers from the above study would make more sense.
Risk of stroke with A fib - commonly assessed with CHADS2 score
CHADS score of 0,1,2,3,4,5 & 6 carries a 1 year stroke risk of ..roughly 2%,3%, 4%, 6%, 8%, 12% & 18% respectively.So we usually start treatment to prevent this thromboembolic risk by starting them on either antiplatelets or warfarin. This question about warfarin or no warfarin always pops up when we see a patient with A fib.
Now lets see the numbers from the above study where they looked at a cohort of 82,000 patients discharged with a diagnosis of Atrial fibrillation. During a follow up period of 3 years ..11%(13,000 pts) had a fatal or non-fatal bleeding.Having warfarin as the standard ..the hazard ratio for the above end point is as follows
For Aspirin alone - 0.93
for plavix alone - 1.06
for aspirin + plavix - 1.66
for aspirin + warfarin - 1.83
for plavix + warfarin - 3.08
for aspirin +plavix+warfarin - 3.70
Clearly this was something that was expected ..based on previous studies. The crude incidence rate of bleeding was 13% for plavix +warfarin, and 15% for triple therapy. So having these numbers ...gives a better idea for making a risk-benefit decision !! ...So ..whoever your pt is....aspirin+plavix+warfarin seems to be a bad combination!
converse outlet, sac louis vuitton pas cher, marc jacobs, replica watches, gucci, ray ban, ugg boots uk, moncler, pandora charms, juicy couture outlet, louis vuitton, barbour, moncler, louis vuitton, canada goose outlet, swarovski, moncler, canada goose outlet, canada goose uk, converse, doudoune canada goose, lancel, barbour jackets, canada goose, canada goose, juicy couture outlet, ugg pas cher, ugg,ugg australia,ugg italia, supra shoes, pandora jewelry, moncler, coach outlet, canada goose, swarovski crystal, louis vuitton, wedding dresses, pandora charms, moncler outlet, toms shoes, montre pas cher, hollister, karen millen, moncler, thomas sabo, louis vuitton, moncler, links of london, ugg,uggs,uggs canada, bottes ugg, pandora jewelry, vans, canada goose, moncler
ReplyDeleteninest123 16.03
Nice Blog
ReplyDelete