High plasma homocysteine levels are associated with cognitive impairment in a few epidemiologic studies.In multiple clinical trials researchers have examined whether vitamin B supplementation — which lowers homocysteine levels — improves cognition or delays onset of cognitive impairment in older adults; results have been mostly negative.Have a look at the Cochrane review from 2008 .But Vitamin B deficiency has been implicated a causative factor for dementia, as it does affect the homocysteine levels.
In a new study published in Neurology 2010, Australian researchers randomized 299 community-dwelling hypertensive men (age>75) without dementia to receive either placebo or a combination of vitamin B6, vitamin B12, and folic acid.
During 2 years of treatment, no differences between groups were noted on several measures of cognition. Even in subgroups in which benefit seemed likely — men with high baseline homocysteine levels (15 µmol/L) and men with mild cognitive impairment at baseline — the investigators found no benefit from vitamin B supplementation.
The study adds more evidence to the fact that vitamin B does not improve cognition ..or prevent or improve dementia. The increased homocysteine levels may just be a marker of dementia than being a predictor of dementia. Its time to look at other things that might be important and probably stop emphasizing on Vitamin B!!
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